NEW YORK — U.S. stocks abruptly changed course again Tuesday and took large losses. Investors worried about the possibility of a weaker global economy and tried to anticipate the Federal Reserve's plans for interest rates. Energy companies fell with the price of oil after a leading industry group said demand for oil is down more than it previously thought.

The price of oil fell 3 percent after the International Energy Agency's remarks about oil demand. The group expects weaker growth because of a more pronounced slowdown in the global economy.

The Dow Jones industrial average gave up 258.32 points, or 1.4 percent, to 18,066.75. The Standard & Poor's 500 index fell 32.02 points, or 1.5 percent, to 2,127.02. The Nasdaq composite lost 56.63 points, or 1.1 percent, to 5,155.26. 

After two months of unusual calm on the markets, stocks have whipsawed over the last few days. They plunged Friday and recovered about half those losses on Monday, only to drop lower Tuesday.